MCQs PAGE - 01

❂ The drug entacapone acts on the ___________________ enzyme.

1) Monoamine oxidase (MAO-B)

2) Dopamine hydroxylase

3) DDC (dopamine decarboxylase)

4) COMT(catechol ortho-methyl transferase)

❂ Which drug is responsible for producing neutropenia and agranulocytosis?

1) Thioureylenes

2) Levothythyroxine

3) Liothyronine

4) Radioiodine

❂ Which drug inhibits thymidine kinase enzyme?

1) Saquinavir

2) Sildenafil

3) Aciclovir

4) Captopril

❂ Which substance is a dopamine (D2) receptor agonist?

1) Ethinylestradil

2) Bromocriptine

3) Isoprenaline

4) Vareniciline

❂ Which drug is responsible for blocking the renal tubule Na+ channel?

1) Amiloride

2) Tetrodotoxin

3) Local anaesthetics

4) Divalent cations(cd+2)

❂ Which drug is an estrogen receptor antagonist?

1) Chlorpromazine

2) Propranolol

3) Tamoxifen

4) Naloxone

❂ Picrotoxin act on the_______________________________.

1) ATP-sensitive K+ channels

2) GABA gated Cl- channels

3) Voltage gated Cl- channels

4) Renal tubule Na+ channels

❂ Plasma has a pH of ___________.

1) 7.2

2) 7.4

3) 3

4) 8

❂ Which protein does warfarin bind to?

1) Albumin

2) β-globulin

3) Tubulin

4) Endothelin

❂ Which medicine is taken by the sublingual route?

1) Tetracycline

2) Indometacin

3) Thyroxine

4) Glyceryl trinitrate

❂ Which medicine is a carbonic anhydrase inhibitor?

1) Fentanyl

2) Dorzolamide

3) Buprenorphine

4) Diazepam

❂ The plasma volume per body weight is _____________.

1) 0.041/kg

2) 0.051/kg

3) 0.061/kg

4) 0.071/kg

❂ The total extracellular volume of the body by weight is ____________.

1) 0.31/kg

2) 0.51/kg

3) 0.41/kg

4) 0.21/kg

❂By weight, the amount of water in the body is ________________.

1) 0.661/kg

2) 0.771/kg

3) 0.551/kg

4) 0.441/kg

❂Which isoenzyme p450 is responsible for the effects of alcohol and paracetamol?

1) CYP2E1

2) CYP2B6

3) CYP1A2

4) CYP2D6

❂ Which p450 isoenzyme is responsible for the metabolism of cyclophosphamide and methadone?

1) CYP2C9

2) CYP2C8

3) CYP1A2

4) CYP2B6

❂ Which sulfonamide compound has anti-epileptic effect?

1) Sulfanilamide

2) Zonisamide

3) Sulfamethoxazole

4) Sulfasalazine

❂ Which drug is responsible for the deficiency of folic acid?

1) Warfarin

2) Omeprazole

3) Ethambutol

4) Phenytoin

❂ What effect does somatostatin have on insulin and glucagon?

1) Increase insulin,decrease glucagon

2) Increase insulin,increase glucagon

3) Decrease insulin, decrease glucagon

40 Decrease insulin,increase glucagon

❂Which drug inhibits both the cardiac output and the release of meditators?

1) Adrenaline

2) Prostacyclin

3) Corticosteroids

4) Dobutamine

❂ Bupropion is contraindicated for the patient with _____________.

1) Seizure

2) Anxiety

3) Diabetes

4) Asthma

❂ Disulfiram is contraindicated for ____________patient.

1) Hypertension 

2) Hypotension 

3) GERD (Gastroesophageal reflux disease)

4) Asthma

❂ Which drug has the highest dependency liability?

1) Ethanol

2) Cannabis

3) Morphine

4) Mescaline

❂ Amitriptyline is used for the treatment of depression and _____________.

1) Anxiety disorder

2) Neuropathic pain

3) Fibromyalgia

4) Bipolar depression

❂ Which medicine is used for the treatment of  fibromyalgia?

1) Nortriptyline

2) Amitriptyline

3) Duloxetine

4) Fluoxetine

❂ Which medication is used in the treatment of depression, anxiety disorder and fibromyalgia?

1) Fluoxetine

2) Olanepine

3) Fluoxetine

4) Sibutramine

❂ Which are the potent anti-inflammatory agent?

1) Selective COX-2 (Cyclooxygenase) inhibitors

2) Non-Selective COX-2 (Cyclooxygenase) inhibitors

3) DMARDS (Disease-modifying antirheumatic drugs )

4) Glucocorticoids

❂ Which is the osmotic laxative?

1) Docusate

2) Lactulose

3) Senna

4) Ispaghula

❂ Which drug is used in the treatment of hyperthyroidism?

1) Levothyroxine

2) Liothyronine

3) Propranolol

4) Cyproterone

❂ Which drug acts by scavenging toxic oxygen metabolites produced by neutrophils?

1) Methotrexate

2) Penicillamine

3) Chloroquine

4) Sulfasalazine

❂ The drug ciclosporin is obtained from ___________.

1) Bacteria

2) Virus

3) Fungus

4) Protozoa

❂ Mercaptopurine is a metabolite of which drug?

1) Azathioprine

2) Mycophenolate mofetil

3) Leflunomide

4) Glucocorticoids

❂ Orlistat is used in the treatment of obesity and is also useful for ______________.

1) Type 2 diabetes

2) Type 1 diabetes

3) Gout

4) Atherosclerosis

❂ Fibrinolytic agents are contraindicated for the following conditions except one:

1) Pregnancy

2) Uncontrolled hypertension

3) Internal bleeding

4) Uncontrolled hypotension

❂ Which adenosine (p2Y) receptor antagonist causes side effects of neutropenia and thrombocytopenia?

1) Ticlopidine

2) Clopidogrel

3) Prasugtel

4) None of the above

❂  Clopidogrel exerts potential action with _____________.

1) Chlorphenaramine

2) Omeprazole

3) Domeperidone

4) Chlorothiazide

❂ Which drug antagonizes the GP 2b/2a receptors(Glycoprotein IIb/IIIa)?

1) Hirudin

2) Ticlopidine

3) Abciximab

4) Clopidogrel

❂ Which medicine reduces the absorption of warfarin in the gut?

1) Colestyramime

2) Carbamazepine

3) Rifampicin

4) Vitamin k

❂ Warfarin has a potentiation of effect in the following disease conditions except one:

1) Liver disease

2) Fever

3) Thyrotoxicosis

4) Hypothyroidism

❂ All of the following drugs enhance the effect of anti-coagulant agents except one:

1) Co-trimoxazole

2) Ciprofloxacin

3) Metronidazole

4) Carbamazepine

❂ Which drug affects vitamin K?

1) Phenylbutazone

2) Cephalosporins

3) Sulfonamide

4) Moxalactum

❂ The following diseases are caused by deficiency of Vitamin K except one:

1) Sprue

2) Celiac disease

3) Steatorrhea

4) Hematomas

❂ Heparin is not absorbed from the gut due to ______________________________.

1) It's charge and high molecular weight

2) It's charge and low molecular weight

3) Interaction with food

4) Interact with flora

❂ Heparin intramuscular injection causes ___________________.

1) Hematomas

2) Thrombophilia

3) Coeliac disease

4) Obstructive jaundice

❂ Which vitamin is made in the intestine?

1) Vitamin K2

2) Vitamin K1

3) Vitamin B6

4) Vitamin B12

❂ Vitamin K is essential for the following clotting factors except one:

1) Factor II (prothrombin)

2) Factor VII 

3) Factor VIII

4) Factor IX (Christmas factor)

❂ The following effects are seen after activation of the ETA(endothelin ) receptor except for one:

1) Vasoconstriction

2) Bronchoconstriction

3) Stimulation of aldosterone secretion

4) Vasodilation

❂ Which prostanoid is used in postpartum haemorrhage?

1) Dinoprostone

2) Misoprostol

3) Carboprost

4) Gemeprost

❂ Which prostanoid is used in primary pulmonary hypertension?

1) Alprostadil

2) Epoprostenol

3) Gemeprost

4) Dinoprostone

❂Which prostenoid is used in open-angle glaucoma?

1) Epoprostenol

2) Alprostadil

3) Latanoprost

4) Misoprostol

❂ Zilutein acts on the _____________ enzyme.

1) 5-lipooxygenase

2) 15-lipoxygenase

3) Glutatione 5-transferase

4) Gamma -glutamyl transpeptidase

❂ What is the size of the virus?

1) 10-20 nm

2) 20-30 nm

3) 30-40 nm

4) 40-50 nm

❂ Which host cell structure does infant diarrheal rotavirus target?

1) Beta-adrenoceptors

2) Helper T lymphocytes CD4 glycoprotein

3) MHC (major histocompatibility complex) molecules

4) T-lymphocyte interleukin-2  receptor

❂ Cold sores are caused by __________________.

1) Varicella zoster

2) Typhi adenovirus

3) Rhino virus

4) Herpes labials

❂ Which derivative is formed by the phosphorylation of zidovudine ?

1) 5-Monophosphate

2) 5-Triphosphate

3) 15-Monophosphate

4) 15-Triphosphate

❂Which mammalian enzyme produces resistance to the zidovudine effect?

1) γ (gamma) - DNA

2) β (beta) - DNA

3) α (alpha) - DNA

4) δ (delta) - DNA

❂ The following medicines are protease inhibitors except one:

1) Amprenavir

2) Atazanavir

3) Indinavir

4) Abacavir

❂Which drug inhibits viral DNA polymerase?

1) Aciclovir

2) Saquinavir

3) Laminadine

4) Zidovudine

❂ Which drug inhibits neuraminidase enzyme?

1) Ratelgravir

2) Saquinavir

3) Indinavir

4) Oseltamivir

❂The drug Tribavirim has a similar structure to ______________.

1) Thymine

2) Thymidine

3) Guanine

4) Guanosine

❂Neuroaminidase is a ______________________.

1) One transmembrane protein

2) Two transmembrane protein

3) Three transmembrane protein

4) Four transmembrane protein