MCQs PAGE - 08

❂ Select appropriate pair:

 

          A.                     

 

1) HIV fusion inhibitor

 

2) Chemokine receptor antagonist

 

3) HIV integrate inhibitor

 

4) Neuraminidase inhibitor

 

        

          B.

 

a) Maraviroc

 

b) Saquinavir

 

c) Enfurvitide

 

d) Ratelgravir

 

e) Oseltamivir

 

Options:

 

1) 1-c,2-a,3-d,4-e

 

2) 1-c,2-a,3-d,4-b

 

3) 1-a,2-d,3-b,4-c

 

4) 1-a,2-d,3-c,4-b

..

 

❂ Which enzyme is responsible for the conversion of leukotriene D4 to leukotriene E4?

 

1) Hydrolase

 

2) Dipeptidase

 

3) γ-Glutamyl transpeptidase

 

4) Glutathiones transferase

 

 

 

❂ Following prostanoids are used in the treatment of glaucoma except for one:

 

1) Bimatoprost

 

2) Misoprostil

 

3) Taluprost

 

4) Latanoprost

 

 

 

❂ Iloprost and epoprost are used in treatment of ___________________ condition .

 

1) Suppressing gastric acid secretion

 

2) Hypotension

 

3) Glaucoma

 

4) Pulmonary hypertension

 

 

 

❂ Lipoxygenase enzyme is found in the following components except one :

 

1) Platelets

 

2) Red blood cells

 

3) Lung

 

4) White  blood cells

 

 

 

❂ Which prostanoid is used to terminate pregnancy?

 

1) Gemeprost

 

2) Dinoprostone

 

3) Carboprost

 

4) Alprostadil

 

 

 

❂  _____________ medication is given to a patient contraindicated for heparin during hemodialysis.

 

1) Alprostadil

 

2) Misoprostol

 

3) Epoprostenol

 

4) Carboprost

 

 

 

❂ From which component is PAF produced ?

 

1) White blood cells

 

2) Platelets

 

3) RBC (red blood cell)

 

4) Neutrophiles

 

 

 

❂ Which medicine is a PAF and histamine antagonist?

 

1) Lexipafant

 

2) Montelukast

 

3) Travoprost

 

4) Rupatidine

 

 

 

❂ Which drug is in clinical trials for the treatment of acute pancreatitis?

 

1) Ratanoprost

 

2) Rupatidine

 

3) Alprostadil

 

4) Lexipafant

 

 

 

❂ Which medicine is used in hereditary angioedema?

 

1) Ribavirin

 

2) Icatibant

 

3) Nitroprusside

 

4) Sildenafil

 

 

 

❂ Endothelin and endothelin receptor are present in the following tissues except one:

 

1) Vascular tissue

 

2) Smooth muscle

 

3) Kidney

 

4) Spleen

 

 

 

❂ Select the incorrect statement for hypothyroidism and its treatment.

 

1) It is caused by iodine deficiency

 

2) Liothyronine and levothyroxine are used in the treatment of hypothyroidism

 

3) Liothyronine has a faster onset but a shorter duration of action

 

4) Radio iodine is used in the treatment of hypothyroidism

 

 

 

❂ Which medicine is an aromatase inhibitor?

 

1) Finasteride

 

2) Anastrozole

 

3) Tamoxifen

 

4) Clomiphene

 

 

 

❂ Which medicine is used in the treatment of infertility?

 

1) Raloxifene

 

2) Tamoxifen

 

3) Clomiphene

 

4) Ethinylestradiol

 

 

❂ Tinea cruris occurs in the _____________.

 

1) Vagina

 

2) Skin

 

3) Hair

 

4) Groin

 

 

❂ Select the appropriate statement for TCA (Tricyclic Antidepressant) drugs :

 

X: TCAs inhibit serotonin, noradrenaline and Dopamine uptake

 

Y: TCAs also inhibit muscarinic ACh receptor

 

Z: Antimuscarinic effect of TCAs also contribute antidepressants action

 

Options:

1) X and Z true,Y is false

 

2) Z and Y false, X is true

 

3) X and Y true ,Z is false

 

4) Z and X false ,Y is true

 

 

 

❂ Which component blocks glycine NMDA co-agonist action?

 

1) 2-Amino, 5- phosphonopentanoic acid (AP5)

 

2) Spermine

 

3) Ifenprodil

 

4) 7-Chlorokynurenic acid

 

 

 

❂ Which statement is false for methyl xanthine?

 

1) Decrease force of myocardial contractions

 

2) Increase force of myocardial contractions

 

3) Increase heart rate

 

4) Causing vagal stimulation

 

 

 

❂  _____________ is not involved for the inhibition of GABA (gamma-amino butyric acid) transport.

 

1) Tiagabine

 

2) Nipecotic acid

 

3) Guvacin

 

4) Perampanel

 

 

 

❂ The following are Ampakines except one:

 

1) Cyclothiazide

 

2) Phencyclidine

 

3) Piracetam

 

4) CX516(Ampalex)

 

 

 

❂ Which anti-epileptic drug is irreversibly inhibiting the enzyme GABA transaminase?

 

1) Benzodizepines

 

2) Phenobarbital

 

3) Vigabatrin

 

4) Tiagabine

 

 

 

❂ Select the incorrect statement for insulin :

 

1) ↑ Glucose uptake

 

2) ↓ Gluconeogenesis

 

3) ↑ Glycogen synthesis              

 

4) ↑ Glycogenolysis

 

 

 

❂ Choose the right option for Plasma Half Life.

 

1) Ethosuximide> phenytoin > carbamazepine> phenobarbital

 

2) Phenobarbital> ethosuximide> phenytoin> carbamazepine

 

3) Phenytoin> carbamazepine> ethosuximide> phenobarbital

 

4) Carbamazepine> ethosuximide> phenobarbital > phenytoin

 

 

 

❂ Minamata disease is caused by _________________.

 

1) Ethylmercury

 

2) Methylmercury

 

3) Lead

 

4) Cadmium

 

 

 

❂ Which anti-epileptic drug has side effects of weight loss?

 

1) Valproate

 

2) Perampanel

 

3) Retigabine

 

4) Zonisamide

 

 

 

❂ Beta- adrenoceptor is the target host of which virus?

 

1) HIV virus

 

2) Rabies virus

 

3) T- cell leukaemia virus

 

4) Infantile diarrhea

 

 

 

❂ The following drug is responsible for inhibition translocation except one:

 

1) Erythromycin

 

2) Spectinomycin

 

3) Chloramphenicol

 

4) Fusidic acid

 

 

 

❂ Which method is helpful for peptide structure determination?

 

1) UV- spectroscopy

 

2) X- ray diffraction

 

3) HPLC

 

4) Nephelometry

 

 

 

❂ nAChRs (nicotinic acetylcholine receptor) are __________________.

 

1) Monomeric

 

2) Tetrameric

 

3) Pentameric

 

4) Dimeric

 

 

❂ The following receptors are responsible for increasing the cyclic AMP except one:

 

1) EP3 (Prostaglandin receptor)

 

2) EP2

 

3) EP3

 

4) DP

 

 

 

❂ Select wrong statement for pramlintide drug : 

 

1) It is amylin analogue with two proline substitute

 

2) It is used in the treatment of  Type 1 and 2 diabetes

 

3) Proline substitution that reduce its tendency to aggregate into insoluble fibrils

 

4) Contraindicated for gastroparesis (loss of gastric motility) patient

 

 

 

 

❂ The following components increase moid effects in a patient with depression except one: 

 

1) Methyldopa

 

2) Tricyclic antidepressants

 

3) MAO (monoamine oxidase) inhibitors

 

4) Electroconvulsive therapy

 

 

 

❂ Which peptide is a mediator of the immune system?

 

1) Angiotensin

 

2) Leptin

 

3) Bradykinin

 

4) Chemokines

 

 

 

❂ The following are plant derived anticancer drugs except one:

 

1) Paclitaxel

 

2) Cisplatin

 

3) Topotecan

 

4) Etoposide

 

 

 

❂ In which condition does warfarin cause hypoplasia of the nose and abnormalities of the central nervous system?

 

1) First trimester

 

2) Second trimester

 

3) Third trimester

 

4) Bone formation stage

 

 

 

❂ Which anesthetic agent has high MAC (minimum alveolar partial pressure)?

 

1) Cyclopropane

 

2) Chloroform

 

3) Sulfur hexafluoride

 

4) Xenon

 

 

 

❂ Which anti-epileptic drug is barbituric acid structural modifying agent ?

 

1) Valproate

 

2) Ethosuximide

 

3) Phenytoin

 

4) Felbamate

 

 

 

❂ Angiotensin-1 is a __________________.

 

1) Tetrapeptide

 

2) Octapeptide

 

3) Dipeptide

 

4) Decapeptide

 

 

 

❂ Somatostatin is made up of ______ amino acids.

 

1) 13

 

2) 14

 

3) 15

 

4) 16

 

 

 

❂ Which hypoglycaemic drug can reduce iodide by thyroid gland ?

 

1) Glibenclamide

 

2) Tolbutamide

 

3) Glipizide

 

4) Metformin

 

 

 

❂ Which drug acts as an anti-obesity drug by inhibiting the reuptake of 5-HT and noradrenaline in the hypothalamic?

 

1) Orlistate

 

2) Sibutramine

 

3) Dinitrophenol (DNP)

 

4) Amphetamine

 

 

 

❂ Which anti-diabetic drug has an effect only when B cells are active?

 

1) Sitagliptin

 

2) Glargine

 

3) Tolbutamide

 

4) Metformin

 

 

 

❂ Which is the precursor of adrenaline synthesis?

 

1) Tryptophan

 

2) Thymine

 

3) Alanine

 

4) Tyrosine

 

 

 

❂ Which anaesthetic agent is a phencyclidine analogue?

 

1) Etomidate

 

2) Midazolam

 

3) Propofol

 

4) Ketamine

 

 

 

 

❂ Which is a vesicular norepinephrine (noradrenaline) inhibitor?

 

1) Cocaine

 

2) Normetanephrine

 

3) Reserpine

 

4) Phenoxyben

 

 

 

❂ Which opioid analgesic drug is a prodrug?

 

1) Methadone

 

2) Diamorphine (heroin)

 

3) Oxycodone

 

4) Sufentanil

 

 

 

❂ Which ergot alkaloid does not act on the 5-HT (serotonin) receptor?

 

1) Ergotamine

 

2) Ergometrine

 

3) Bromocriptine

 

4) Methysergide