MCQs PAGE - 11

❂ Syphilis is caused by which microorganism?

1) Chlamydia trachomatis

2) Treponema pallidum

3) Salmonella typhimurium

4) CampylobacteIDr jejuni

❂ Whooping cough is caused by _______________ microorganism.

1) Brucella abortus

2) Bordetella pertussis

3) Haemophilia

4) Klebsiella pneumoniae

❂ Sulfonamide is the structural analog of ______________________________.

1) GABA (Gamna amino butyric acid)

2) PABA (P-amino benzoic acid)

3) NMDA ( N-methyl-D-aspartate)

4) AMPA (Glutamatergic receptor)

❂ What pathway do sulfonamides act on?

1) Inhibit folic acid synthesis

2) Stimulate folic acid synthesis

3) Inhibit thymidine synthesis

4) 1&3

❂  _______(a)________ and _____(b)__________ together form Co-trimoxazole 

1) a-Sulfamethoxazole,  b-Salfasalazine

2) a-Sulfamethoxazole, b-Trimethoprim

3) a-Sufadiazine, b-Trimethoprim

4) a-Sufadiazine, a-Sulfamethoxazole

❂ Which drug has the antagonist sulfonamide that produces the antibacterial effect?

1) Warfarin

2) Ampicillin

3) Procaine

4) Salbutamol

❂ Which antibiotic acts on the structure of the outer cell membrane of bacteria in gram negative?

1) Tetracycline

2) Macrolides

3) Streptogramins

4) Polymixins

❂ Which class is responsible for the adverse effects of gray baby syndrome?

1) Aminoglycisides

2) Macrolides

3) Cephalosporins

4) Amphenicols

❂ _____________________________ is the mechanism of action of a beta-lactams antibiotic.

1) Act on bacterial cellwall peptidoglycan synthesis

2) Act on bacterial protein synthesis

3) Act on bacterial folate synthesis

4) Act on bacterial RNA synthesis

❂ Which sulfonamide drug is similar to the teridine fraction of folate?

1) Sufadiazine

2) Trimethoprim

3) Sulfamethoxazole

4) Sufadiazine

❂ Which sulfonamide drug is chronically related to the anti-malarial drug pyrimethamine?

1) Trimethoprim

2) Sulfasalazine

3) Sulfamethoxazole

4) Sufadiazine

❂ Megaloblastic anemia like side effect of trimethoprim overcome by _____________________.

1) Sulfasalazine

2) Folinic acid

3) Pyrimethamine

4) Trimethoprim

❂ PABA is converted to folate by the ____________________________ enzyme.

1) Dihydropteroate reductase

2) Dihydropteroate synthetase

3) Dihydrofolate reductase

4) Dihydrofolate synthetase

❂  Which enzyme is responsible for the effect of Trimethoprim?

1) Dihydropteroate synthetase

2) Dihydrofolate reductase

3) Tetrahydrofolate reductase

4) Tetrahydropteroat synthetase

❂ Which sulfonamide is used for infected burns?

1) Trimethoprim

2) Sulfasalazine

3) Co-trimoxazole

4) Silver sulfadiazine

❂Co-trimoxazole  is used  against ___________________________microorganism.

1) Pneumocystis jirovecii

3) Bordetella pertussis

3) Bacillus anthracis

4) Yersinia pestis

❂ ______________________inhibits the transpeptidation enzyme of peptidoglycan.

1) Cephalosporins

2) Sulfonamide

3) Cephamycins

4) β-lactam antibiotic

❂ The following drugs are β-lactamase-resistant penicillins except one:

1) Meticillin

2) Ampicillin

3) Flucloxacillin

4) Temocillin

❂ Which is the broad spectrum penicillin class of drug?

1) Ampicillin

2) Temocillin

3) Piperacillin

4) Ticarcillin

❂ Which is extended-spectrum penicillin?

1) Amoxicillin

2) Temocillin

3) Piperacillin

4) Ticarcillin

❂ Co-trimoxazole is used in the treatment of ________________________.

1) Skin and soft tissue infection

2) Bronchitis

3) Animal bites

4) Pharyngitis

❂ Penicillin intrathecal administration leads to __________________ side effects.

1) Neurotoxicity

2) Nephrotoxicity

3) Convulsions

4) Delirium

❂ Which penicillin class of drug is used to treat bone and joint infections?

1) Benzyl penicillin

2) Amoxicillin

3) Ticarcillin

4) Flucloxacillin

❂ Penicillin is used in __________________________.

1) Procaine benzyl penicillin

2) Penicillin

3) Amoxicillin

4) Ticarcillin

❂ Which penicillin class of drug is used in syphilis?

1) Benzyl penicillin

2) Penicillin V

3) Amoxicillin

4) Procaine benzyl penicillin

❂_____________________ is the infantile diarrhea virus host cell structure.

1) MHC molecules

2) T-lymphocyte interleukin-2 receptor

3) Acetylcholine receptor on skeletal muscle

4) β- adrenoceptors

❂ Viral DNA transcription into mRNA catalyzed by _________________enzymes in the host.

1) RNA polymerase

2) DNA polymerase

3) RNA ligase

4) DNA ligase

❂ In retroviruses, the virion contains a __________________enzyme.

1) Reverse transferase enzyme

2) Reverse transcriptase enzyme

3) Reverse synthetase enzyme

4) Reverse ligase enzyme

❂ Which protein is present on the coat of the structure of the virus?

1) Nucleomere

2) Lipomere

3) Capsomere

4) Lymere

❂ Which virus is responsible for chickenpox and shingles?

1) Varicella zoster

2) Herpes labialis

3) Retroviruses

4) Adeno virus

❂ Zidovudine is used in HIV and is also used in_____________________________.

1) Diabetes

2) Tuberculosis

3) Hepatitis B

4) Jaundice

❂ Which drug is a non-nucleoside reverse transcriptase inhibitor?

1) Zidovudine

3) Amprenavir

3) Ritonavir

4) Nevirapine

❂ Which  is the prodrug of amprenavir?

1) Lopinavir

2) Fosamprenavir

3) Timpranavir

4) Saquinavir

❂ The following medicines are protease inhibitors except one:

1) Amprenavir

2) Atazanavir

3) Efavirenz

4) Zanamivir

❂ Which non-nucleoside reverse transcriptase inhibitor has teratogenic side effects?

1) Nevirapine

2) Efavirenz

3) Enfurvitide

4) Zanamivir

❂ The drug ganciclovir is used to treat megalovirus infection by acting on the______________________enzyme. 

1) Integrase

2) Viral DNA polymerase

3) Chemokine receptor

4) Protease

❂Which antiviral drug prevents viral capsule disassembly?

1) Amantadine

2) Lamavudine

3) Oseltamivir

4) Rategravir

❂Meningitis is caused by which organism?

1) Cryptococcus neoformans

2) Candida albicans

3) Histoplasma capsulatum

4) Aspergillus fumigatus

❂Pulmonary aspergillosis is caused by which microorganism?

1) Aspergillus Niger

2) Aspergillus fumigatus

3) Aspergillus albicans

4) Aspergillus neoformans

❂ Which of the following microorganisms are responsible for tinea or ringworm?

1) Trichophyton spp.

2) Epidermophyton

3) Blastomyces dermatides

4) Microsporum spp.

❂Which part of the body is affected in tinea capitis?

1) Hair

2) Skin

3) Scalp

4) Feet

❂All the medicines given below are used in pruritus disease except one:

1) Crotamiton

2) Diphenhydramine

3) Acitretin

4) Doxepin

❂Which drug is active against influenza A and B viruses?

1) Zanamivir

2) Oseltamivir

3) Foscarnet

4) 1&2 both

❂ Which drug prevents the fusion of HIV with host cells?

1) Amantadine

2) Maraviroc

3) Enfurvitide

4) Cidofovir

❂ The following drugs are biopharmaceutical antiviral-drug except one:

1) Immunoglobulin

2) Interferon(IFNs)

3) Monoclonal antibodies

4) Interleukin

❂ Hyperimmunoglobulin is present in all of the following virus infections except one:

1) Hepatitis B

2) Poliomyelitis

3) Varicella zoster

4) Rabies

❂   ______________________is immune interferon.

1) IFN-α 

2) IFN-β

3) IFN-γ

4) IFN-δ

❂What is icatibant?

1) Selective competitive   β1-adrenergic blocker 

2) Selective competitive   β2 adrenergic blocker 

3) Non-Selective competitive β2 adrenergic blocker 

4) Non-Selective competitive β1-adrenergic blocker 

❂  Interferon α-2b is used in the treatment of ___________________________.

1) Hepatitis B infection

2) AIDS infection

3) Hepatitis A infection

4) Hepatitis C infection

❂Which type of conjugation of IFNs (Interferon) has a longer lifetime in circulation?

1) Pegylated IFNs(polyethylene glycol)

2) Acetylated IFNs(acetic acid)

3) Amylated IFNs(amino group)

4) Acylated IFNs(acylation reaction)