MCQs PAGE - 10

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❂ The following medicines act as vasodilators indirectly except for one:

 

1) Ramipril

 

2) Nifedipine

 

3) Aliskiren

 

4) Losartan

 

 

❂ Which is an Angiotensin-converting-enzyme inhibitors?

 

1) Losartan

 

2) Sildenafil

 

3) Bosentan

 

4) Ramipril

 

 

❂ Which drug is the antagonist of H1 (Histamine) and PAF (Platelet-activating factor) receptor ?

 

1) Rupatidine

 

2) Lexipafant

 

3) Zileutin

 

4) Icatibant

 

 

 

❂ Which receptor respond to des-arg-bradykinin?

 

1) kinin B1 receptors

 

2) kinin B2 receptors

 

3) IL-1 (Interleukin 1) receptor

 

4) IL-2  (Interleukin 1) receptor

 

 

❂ IFN α2a (Interferon) is used in the treatment of __________________.

 

1) Hepatitis A

 

2) Hepatitis B

 

3) Hepatitis C

 

4) Poliomyelitis

 

 

❂ Select incorrect pharmacological action of bradykinin.

 

1) Vasodilation

 

2) Increased vascular permeability

 

3) Stimulation of pain nrve endings

 

4) Relaxation of intestinal and uterine smooth muscle

 

 

 

❂ Which is a selective competitive antagonist of the B1 (bradykinin) receptor?

 

1) Des-Arg Hoe 240

 

2) Des-Arg Hoe 140

 

3) Icatibant

 

4) Dimaprit

 

 

 

❂ What is receptor made of ?

 

1) Lipids

 

2) Protein

 

3) Carbohydrates

 

4) Polypeptide

 

 

❂ In which part do T (lymphocyte) cells mature ?

 

1) Hepatocytes

 

2) Erythrocytes

 

3) Bone marrow

 

4) Thymus

 

 

❂  ________________is a prodrug of ganciclovir.

 

1) Valganciclovir

 

2) Valaciclovir

 

3) Penciclovir

 

4) Famciclovir

 

 

❂ Which drug is used in digoxin toxicity?

 

1) Atropine

 

2) Isoprenaline

 

3) Magnesium chloride

 

4) Calcium chloride

 

 

 

❂ Erythropoietin is produced in which part of the kidney?

 

1) Proximul tubul

 

2) Juxta tubbular

 

3) Collecting tubule

 

4) Distal tubule

 

 

 

❂ Which statement is true for erythropoietin?

 

1) Regulates white cell production

 

2) Regulates platelets production

 

3) Regulates red cell production

 

4) Regulates neutrophils Progenitors

 

 

 

❂ Methyl malonyl-CoA isomerization to succinyl-CoA by _________________.

 

1) Vitamin B12

 

2) Folic acid

 

3) Vitamin B6

 

4) Vitamin C

 

 

 

❂ Which transport protein does Ezetimibe block?

 

1) NPC1L2 (Niemann-Pick C1-Like)

 

2) NPC1L1

 

3) NPC2L1

 

4) NPC2L2

 

 

❂ The following are the effects produced by statins except for one:

 

1) Reduced vascular inflammation

 

2) Reduced platelets aggregation

 

3) Enhanced fibrinolysis

 

4) Decreased neovascularisation of ischaemic tissue

 

 

❂ Fish oil derivatives are_______________________,___,,_.

 

1) Omega-4 marine triglycerides

 

2) Omega-3 marine triglycerides

 

3) Omega-2 marine triglycerides

 

4) Omega-1 Marine triglycerides

 

 

 

❂ Which drug is used in the treatment of refractory angina?

 

1) Nicorandil

 

2) Levosimenelan

 

3) Nitroprusside

 

4) Nesiritide

 

 

❂ Which is a selective PDE (phosphodiesterase) type 3 inhibitor?

 

1) Theophylline

 

2) Milrinome

 

3) Papaverine

 

4) Sildanafil

 

 

❂ How many times more powerful is angiotensin- 2 than adrenaline in raising blood pressure?

 

1) 20 times

 

2) 30 times

 

3) 40 times

 

4) 50 times

 

 

 

❂ Which component gives both vasoconstriction and vasoconstriction action?

 

1) Angiotensin 2

 

2) ADH (Antidiuretic hormone)

 

3) α1- Adrenoceptor agonist

 

4) Endothelin

 

 

 

❂ Which is the powerful vasoconstrictor?

 

1) Angiotensin

 

2) ADH (Antidiuretic hormone)

 

3) Endothelin

 

4) α1- Adrenoceptor agonist

 

 

❂ A 70 kg man has about ________ of iron in his body.

 

1) 5 g

 

2) 4 g

 

3) 7 g

 

4) 9 g

 

 

 

❂ By what mechanism does the Echinocandins antifungal drug work?

 

1) Binding fungal microtubules

 

2) Inhibit canosine 142-demethylase

 

3) Action on ergosterol

 

4) Inhibit the synthesis of 1,3-Beta-glucan

 

 

 

❂ _________________ is hook worm.

 

1) Strongyloides stercoralis

 

2) Anhylostoma duodenale

 

3) Trichuris trichiura

 

4) Enterovirus veemicularis

 

 

 

❂ Which anthelmintic drugs interfere with helmintic arachidonate metabolism?

 

1) Diethyl carbamazepine

 

2) Niclosamide

 

3) Piperazine

 

4) Levamisole

 

 

 

❂ Which worm causes elephantiasis?

 

1) Dracunculus medinensis

 

2) Wuchereria Bancrofti

 

3) Onchocerca volvulus

 

4) Trichenella spiralis

 

 

 

❂ Which class of antimalarial drug blocks electron transport energy generation?

 

1) Diamine pyridins

 

2) Biguanides

 

3) Hydroxy naphthoquinones

 

4) Quinolones

 

 

 

❂ Which drug causes hirsutism?

 

1) Diazoxide

 

2) Nicorandil

 

3) Lovosimendan

 

4) Minoxidil

 

 

 

❂ The mechanism of action of cocaine is __________________________.

 

1) Noradrenaline (norepinephrine) release

 

2) Blocks noradrenaline reuptake

 

3) Endothelin release

 

4) Block Endothelin

 

 

 

❂ At which threshold is rapid depolarization (phase 0)?

 

1) -60 mV

 

2) -50 mv

 

3) -40 mv

 

4) -30 mv

 

 

 

❂ The conduction velocity of the nodal region is _________.

 

1) ~ 10 cm/s

 

2) ~ 5 cm/s

 

3) ~ 100 cm//s

 

4) ~ 100 cm/s

 

 

 

❂ Which statement is correct for SVT (supraventricular tachycardia) ?

 

1) Heart beat is slow but regular

 

2) Heart beat is slow but irregular

 

3) Heart beat is rapid but irregular

 

4) Heart beat is rapid but regular

 

 

❂ Complete cessation of electrical activity of heart is called

________________.

 

1) Systolic arrest

 

2) Asystolic arrest

 

3) Diastolic arrest

 

4) Adiastolic arrest

 

 

❂ Which is the main reason for the delay after depolarization?

 

1) Abnormally raised K+

 

2) Abnormally raised Ca+2

 

3) Abnormally raised Na+

 

4) Abnormally raised Cl-

 

 

❂ Which mechanism is responsible behind cardiac membrane depolarization?

 

1) Transfer 2 Ca+2 ions out and entry of 3 Na+ ions

 

2) Transfer 1 Ca+2 ion out and entry of 2 Na+ ions

 

3) Transfer 1 Ca+2 ion out  and entry of 3 Na+ ions

 

4) Transfer 3 Ca+2 ion out and entry 1 Na+ ion

 

 

 

❂ Sibutramine drug is used in ___________ condition.

 

1) Obesity

 

2) Diabetes mellitus

 

3) Diabetes insipidus

 

4) Atherosclerosis

 

 

 

❂ Which antifungal drug inhibit steroidogenesis in overdose ?

 

1) Intraconazole

 

2) Miconazole

 

3) Ketoconazole

 

4) Fluconazole

 

 

 

 

❂ Which hypoglycaemic drug inhibits α-glucosidase inhibitor?

 

1) Metformin

 

2) Tolbutamide

 

3)  Pioglitazone

 

4) Acarbose

 

 

 

❂ Does sitagliptin act on which enzyme?

 

1) dipeptidyl peptidase-3 (DPP-3)

 

2) DPP-2

 

3) DPP-1

 

4) DPP-4

 

 

❂ Which hypoglycaemic drugs decrease hemoglobin A1c?

 

1) Acarbose

 

2) Sitagliptin

 

3) Piogliptazone

 

4) Glibenclamide

 

 

 

❂ Which hypoglycaemic drug class has a neutralizing action on weight?

 

1) Biguanides

 

2) Gliptins

 

3) Sulfonylureas

 

4) α-glucosidase inhibitor

 

 

❂ Select appropriate statement.

 

X : GIP (Gastric inhibitory polypeptide)  is a 42- amino acid peptide and secreted in K cell in duodenum and proximal jejunum

 

Y : GLP-1 (Glucagon-like peptide) is secrete before a meal

 

Z : GLP-1 is secrete by L cells and widely distributed in the gut

 

1) x and y false, z true

 

2) y and z true, x false

 

3) x and z true, y false

 

4) z and x false, y true

 

 

 

❂ Which neurotransmitter is somewhat similar to glucagon?

 

1) Histamine

 

2) Dopamine

 

3) 5-HT (5- hydroxy tryptamine)

 

4) Adrenaline

 

 

 

❂ Which substance is used in the treatment of acute heart failure precipitated by B-adrenoceptor antagonism?

 

1) Somatostatin

 

2) Glucagon

 

3) Amylin

 

4) Increatin

 

 

 

❂ Select appropriate statement for insulin :

 

X : Decreasing glucogenesis

 

Y : Increase glucose uptake into muscle and fat via Glut-4

 

Z : Increasing glycogen break down

 

1) X and Z true, Y false

 

2) X and Y true, Z false

 

3) Y and Z true, X false

 

4) X,Y,Z are true

 

 

 

❂ Which is a non-nucleoid RTI (reverse transcriptase inhibitor) ?

 

1) Zidovudine

 

2) Abacavir

 

3) Saquinavir

 

4) Nevirapine

 

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