MCQs PAGE - 04

❂  _______________factor is responsible for coagulation.

 

1) Thrombin I

 

2) Thrombin II

 

3) Thrombin IV

 

4) Thrombin IX

 

 

 

❂ Which drug has both antidyarrhythmic and antiepileptic properties?

 

1) Verapamil

 

2) Carbamazepine

 

3) Phenytoin

 

4) Propranolol

 

 

 

❂ All of the following stimulate prolactin secretion except one:

 

1) Bromocriptine

 

2) Oestrogen

 

3) Clozapine

 

4) Haloperidol

 

 

 

❂ Select appropriate options:

 

X: Ethosuximide is the drug of choice for absence seizure

 

Y: The 5-HT agonist sumatriptan is used in anxiety

 

Z : The active metabolite of dacarbazine acts as an alkylating agent

 

V : Bacitracin is responsible for blocking rephosphorylation

 

T : Phenytoin causes anemia

 

Options:

1) X,Y, Z True,V&T false

 

2) X, Z, T true,Y&V false

 

3) X, Z, T false,Y& T true

 

4) X, Y, X false,V&T true

 

 

 

❂ Choose the wrong option for histamine and histaminergic drug:

 

1) Promethazine does not induce sleep during therapy

 

2) Cyclizine is useful for treating motion sickness

 

3) Cimetidine has gynecomastia adverse effects

 

4) Histamine is released from mast cells

 

❂❂  Which benzodiazepine class of medication is used specifically in mania?

1) Zolpidem         

2) Flurazepam 

3) Alprazola       

4) Clonazepam

 ❂ Which receptor is not the  EEs (excitatery amino acid ) receptor?

1) AMPA    

2) NMDA  

3) Metabotropic     

4) GABAA receptor                             

❂❂ All of the Following are neurotransmitters are amino acids except one.

1) GABA  (Gamma-Amino butyric acid)

2) GLYCIN      

3) ACH (Acetylcholine)

4) GLUTAMATE.

❂ Which muscarinic receptor is present in the heart ?

1) M1     2) M2    3) M3    4) M4

❂  All of the following are Muscarinic antagonists except one :

1) ATROPINE      

2) DICYCLOMINE

3) CARBACHOL  

4) IPRATROPIUM

❂ Which is the precursor of ACh (acetylcholine) synthesis?

1) Choline-ester

2) Choline  

3) Alanine

4) Co-A (Coenzyme-A)

❂ Which  receptor is a ligand-gated ion channel receptor? 

1) Muscarinic receptor   

2) Nicotinic receptor 

3) Prostaglandin EP-receptor             

4) Prostaglandin F-receptor

❂ Which one is  the antagonist of CysLT (Cysteinyl-leukotriene) receptor ?

1) Misoprostol     

2) Latanoprost 

3) Montelukast    

4) Mepyramine.

❂ It is caused by inhibition of Cyclic adenosine monophosphate (cAMP)........

1) ↓ca+2 (calcium) conductance   

2) ↑ca+2 (calcium) conductance

3) ↓k+(potassium) conductance         

4) none of the above

❂ Which muscarinic antagonist  is used in peptic ulcer ?

1) Atropine           

2) Ipratropium 

3) Tropicamide    

4) Pirenzepine

❂ Identify  carbonic anhydrase inhibitor.

1) Pilocarpine      

2) Acetazolamide  

3) Clonidine         

4) Latanoprost

❂ Select the appropriate effect of atropine on the heart.

1) Bradycardia      

2) 50-60 beats/min  Heart rate

3) Tachycardia.      

4) No effect on heart

❂ Which is a α2(Alpha-2) adrenergic agonist?

1) Acetazolamide  

2) Latanoprost

3) Cyclopentolate  

4) Clonidine

❂ Which is a prostaglandin analogue?

1) Pirenzepine    

2) Hyoscine

3) Latanoprost    

4) Physostigmine

❂ All the given below are nicotinic receptor agonists except one : 

1) Lobeline                

 2) Epibatidine

3) Suxamethonium

4) Hexamethonium

❂ Which neuromuscular blocking substance causes hypotension as a side effect?

1) Mivacurium  

2) Tubocurarine

3) Gallamine      

4) Suxamethonium.

❂ Phenylethanolamine N-methyltransferase (PNMT) enzyme is located in____________________________.

1) Adrenal medulla  

2) Cytosol.

3) Nerv endings          

4) Medula oblongata

❂  _________________________is a metabolite of adrenaline.

1) Trihydro mandelic acid

2) Dihydro mandelic acid

3) Dihydro dopamine

4) Trihydro dopamine

❂ Which is the precursor of 5-HT (Hydroxytryptamine) synthesis?

1) Alanine          

2) Tyrosin

3) Tryptophan    

4) Choline

❂Which enzyme participates in the 5-HT (hydroxytryptamine) metabolic process?

1) Monoamine hydroxylase

2) Monoamine oxidase

3) Tryptophan hydroxylase

4) Aldehyde carboxylase

❂ Which benzodiazepine class of drug is administered intravenously ?

1) Lorazepam    

2) Flurazepam   

3) Midazolam    

4) Clonazepam

❂ In which part do B lymphocytes mature?

1) Phagocyte

2) Thymus

3) Bone marrow

4) Macrophage

❂ Which is the first synthesized benzodiazepine?

1) Oxazepam    

2) Chlordiazepoxide

3) Alprazolam  

4) Nitrazepam

❂ Which 5-HT1A (5-hydroxytryptamine) agonist act as anxiolytics?

1) Buspirone    

2) 8-oh--DPAT

3) 5-CT  (5-Carboxamidotryptamine)     

4) Ergotamine

❂ Which muscarinic antagonist is used in motion sickness?

1) Ipratropium      

2) Tropicamide 

3) Pirenzepine       

4) Hyoscine

❂ Which muscarinic agonists are widely used in eye drops?

1) Timolol           

2) Latanoprost 

3) Pilocarpine   

4) Acetazolamide

❂ The medicines given below are intraheumatic drugs except one : 

1) Sulgasalazine        

2) Methotrexate

3) Gold compounds   

4) Basiliximab

❂ Which substance inhibits macrophage action?

1) Methotrexate        

2) Glucocorticoids 

3) Sulfasalazine        

4) Chloroquine

❂ Which medicine is not used in migraine?

1) Ergometrine       

2) Ergotamine 

3) Methylsergide    

4) Dihydro-ergotamine

❂ IFN-α (Interferon-alfa) is used for the treatment of _________________________.

1) Tuberculosis

2) Multiple sclerosis 

3) Chronic hepatitis B   

4) Asthma

❂ Interferon-β (IFN-β) is used for the treatment of _________________________.

1) Blood cancer 

2) Pneumonia

3) Hepatitis C          

4) Multiple sclerosis

❂ Interferon gamma (IFN-γ)is used for the treatment of _________________________. 

1) Arthritis      

2) Granulomatous 

3) Cold             

4) Glaucoma

❂ What is the role of NO (Nitric Oxide) in our body?

1) Inflammation

2) Amino acid synthesis

3) Muscle tonicity 

4) CNS stimulation

❂ Ergotamine Drug is Contraindicated to___________________Patient.

1) Anxiety          

2) Parkinson's disease 

3) Peripheral vascular disease

4) Insomnia

❂ Which ergot alkaloid is the potent 5-HT2 receptor antagonist?

1) Ergotamine                

2) Methysergide 

3) Dihydroergotamine  

4) Bromocriptine

❂  Which peptide is used in the treatment of high blood pressure and heart failure?

1) Oxytocin        

2) Insulin

3) Captopril        

4) Ciclosporin

❂ Which protein is used in the treatment of anemia?

1) Asparaginase   

2) Erythropoietin

3) Interferons       

4) Streptokinase

❂ Lidocaine given intravenous infusion to treat ______________patient.

1) Anxiety      

2) Hypertension

3) Ventricular dysrhythmia

4) Hypotension

❂ Anticoagulant drugs are not given in this condition :

1) Thrombosis in patients with ventrial fibrillation

2) Clotting in extracorporeal circulation

3) Deep vein thrombosis

4) Perioperatively

❂ Which antiplatelet drug  is thienopyridine derivative?

1) Epoprostenol    

2) Aspirin

3) Sulfinpyrazone

4) Ticlopidine

❂ ________________is responsible for pacemaker activity in the heart.

1) SA node          

2) AV node

3) Ventricals        

4) Purkinje fibres

❂ On which enzyme does the allopurinol drug act?

 

1) Xanthine decarboxylase 

2) Xanthine oxidase

3) Xanthine transferase 

4) Xanthine hydroxylase

❂Which drug inhibits cytokine gene expression?

1) Cilcosporin

2) Myclophenolate mofetil 

3) Azathioprine

4) Corticosteroids

❂ Which drug inhibits the production or action of IL-2 (Interleukin-2)?

1) Tacrolimus

2) Azathioprine

3) Monoclonal antibodies

4) Corticosteroids 

❂ Glucocorticoids act on ___________________ to treat gout.

1) T CD4 cell (T helper cell) 

2) Macrophage

3) Fibroblast 

4) Osteoclast

❂ What is the mechanism of action of Colchicine?

1) Inhibition of PG (Prostaglandin) synthesis

2) Inhibition of xanthine oxidase

3) Stimulation of PG (Prostaglandin) synthesis

4) Inhibitor of  leucocyte migration

❂ Which is a uricosuric agent?

1) Mercaptopurine

2) Azathioprine

3) Probenecid

4) Cyclophosphamide

❂ In which disease gold compounds are used?

1) Epilepsy

2) Parkinsonism

3) Gout

4) Rheumatoid arthritis

❂ Which is a GABAA selective agonist

1) Baclofen

2) Strychnine

3) Picrotoxin

4) Alphaxolone

❂  Which substance blocks the NMDA receptor?

1) Raloxifene

2) Risedronate

3) Memantine

4) Alendronate