MCQs PAGE - 03

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❂ Which alkaloid inhibits the transport of noradrenaline in very low concentrations?

1) Strychnine 

2) Brucine

3) Emetine

4) Reserpine


❂ Which drug inhibits Na+/cl- carriers?

1) Pramlintide

2) Thiazide 

3) Octreotide

4) Glargine


❂ Somatostatin is secreted by___________________________.

1) Astrocyte

2) Nerve terminal

3) D-cells of the islets

4) Adrenal gland


❂ Glucagon synthesis occurs by __________________________.

1) A-cell of the islets

2) B-cell of the islets

3) C-cell of the islets

4) D-cell of the islets


❂ If glucagon secretion is high: ____(a)_____ level of glucose concentration will be observed and If glucagon secretion is low:____(b)_____level of glucose concentration will be observed.

1) a- Low ,  b-Normal

2) a- Low ,  b-High

3) a-High,   b-Low

4) a-High,   b-Normal


❂ Low Identify the following correct pairs.

Agonist                                           antagonist 

A) Baclofen                                  1) Butaxamine

B) Glycine                                    2) Phaclofen

C) Salmeterol                               3) Prazosin

D) Phenylephrine                        4) Strychnine

Options:
1) A-2,B-4,C-1,D-3
2) A-2,B-3,C-1,D-4
3) A-1,B-4,C-3,D-2
4) A-1,B-4,C-2,D-3



❂ Which anti-depressant drug is additionally responsible for its anti-obesity action?

1) Imipramine

2) Amitriptyline

3) Sibutramine

4) Moclobemide


❂ Combination therapy of MAO and SSRI causes _______________.

1) Gangrene

2) Cushing's syndrome

3) Johnson's syndrome

4) Hodgkin's disease


❂  __________opiate has non-analgesic action.

1) Pethidine

2) Methyl morphine

3) Pholcodine

4) Fentanyl


❂ Which one is semisynthetic thebaine derivative?

1) etorphine

2) methadone

3) pethidine

4) nalorphine


❂ Carbamazepine competes with  TCA (tri cyclic anti-depressant) and increases its potency.

1)  Picrotoxin

2) Alphaxolone

3) Clomipramine

4) Aspirin


❂ Which compound is derived from nature and blocks  fast inhibitory synaptic potential?

1) Morphine

2) Thebaine

3) Bicuculline

4) Cephaline



❂  _______________ of ​​the brain has the highest amount of GABA (gamma-Aminobutyric acid).

1) Grey matter

2) Nigrostriatal

3) Limbic system

4) Mesolimbic pathway


❂ Which drug inhibits the GABA transaminase enzyme?

1) Picrotoxin

2) Flumazenil

3) Cycloythiazide

4) Vigabatrine


❂ What is a metabolite of 5-HT (Hydroxytryptamine)?

1) 6-Hydroxyindoleacetic acid

2) 5-Hydroxyindoleacetic acid

3) 6-Aminoindoleacetic acid

4) 5-Aminoindoleacetic acid


❂  ___________________________is a metabolite of noradrenaline

1) 3-Methoxy -5-hydroxyphenylglycol

2) 4-Methoxy -5-hydroxyphenylglycol

3) 4-Methoxy -3-hudroxyphenylglycol

4) 3-Methoxy -4-hydroxyphenylglycol



❂ Positive chronological effect means ___________________________.

1) Decreased heart rate 

2) Increased heart rate

3) Decreased automaticity

4) Stimulate parasympathetic system


❂ Which medicine is used in variant angina?

1) Organic nitrates

2) Methysergide

3) Adrenaline

4) Dobutamine


❂ Which 5-HT3 (serotonin)  antagonist drug is used in vomiting?

1) Ondansetron

2) Methysergide

3) Domperidol

4) Diphenhydramine


❂ _______________ is a class-1 antidyarrhythmic drug.

1) Propranolol

2) Timolol

3) Lidocaine

4) Metoprolol


❂ Which medicine has atropine-like effect?

1) Disopyramide

2) Lidocaine

3) Amiodarone

4) Atenolol



❂ The following symptoms are for stable angina except one : 

1) Pain on exertion

2) Pain on less exertion

3) Narrowing of the coronary vessels

4) Atheroma


❂ Which heart disease is caused by a coronary artery blocked by a thrombus?

1) Angina

2) Unstable angina

3) Myocardial infarction

4) Variant angina


❂ The following drugs are used in myocardial ischemia except one:

1) Thrombolytic drugs

2) Aspirin

3) Nitrates

4) Omeprazole


❂ Which drug inhibits sympathetic activity and dysrhythmia in heart disease?

1)  β- Adrenoceptor agonists

2)  β- Adrenoceptor antagonists

3)  α- Adrenoceptor agonists

4) α- Adrenoceptor antagonists


❂ Digoxin is used in the treatment of ______________________.

1) Cardiac arrest

2) Sinus bradycardia

3) Heart attack

4) Rapid atrial fibrillation


❂ __________________________________ is the mechanism of action of disopyramide

1) Blocking the NA+ channel with intermediate dissociation

2) Blocking the NA+ channel with fast dissociation

3) Blocking the NA+ channel with slow dissociation

40 Blocking the K+ channel with  slow dissociation


❂ What is the mechanism of action of Verapamil?

1) Blocking  K+ channel

2) Blocking  NA+ channel

3) Blocking  Ca++ channel

4) 1 &2 both


❂ Adenosine is used in the treatment of _________________________________.

1) Sinus bradycardia

2) Heart attack

3) Supraventricular tachycardia

4) Ventricular fibrillation


❂ Which substance is a K+ channel activator?

1) Nicorandil

2) Amylnitrate

3) Mononitrate

4) Spironolactone



❂ The following medicines are endothelin antagonists except one:

1) Bosentan

2) Sildenafil

3) Ambrisentan

4) Sitaxentan


❂ Which is a phosphodiesterase V inhibitor?

1) Sildenafil

2) Beraprost

3) Sitaxentan

4) Nifedipine


❂  Which drug is a glycine antagonist?

1) Bicuculline

2) Gabazine

3) Strychnine

4) Diazepam



❂ Which substance in antiplatelet activity acts as a thrombin inhibitor?

1) Tirofiban

2) Hirudin

3) Abciximab

4) Epoprostenol


❂ The mechanism of action of aspirin is by_____________________________.

1) Inhibiting COX enzyme

2) Inhibiting  of thrombin

3) Inhibiting  of Thromboxane A2 transferase

4) Inhibiting  of phosphodiesterase enzyme


❂Which drug blocks the P2y12 (adenosine diphosphate) receptor?

1) Dipyridamole

2) Epoprostenol

3) Abciximab

4) Clopidogrel


❂ Which drug inhibits the phosphodiesterase enzyme?

1) Aspirin

2) Clopidogrel

3) Dipyridamole

4) Tirofiban



❂ The mechanism of action of tranexamic acid is_____________________________.

1) Inhibiting thrombin

2) Inhibiting COX enzyme

3) Inhibiting phosphodiesterase

4) Inhibiting plasminogen activation



❂ Which drug is responsible for side effects like bone marrow suppression?

1) Anticancer

2) Clozapine

3) Pyridoxine

4) 1&2 both


❂ In heart failure patient, the concentration of BNP (Brain natriuretic peptide) in the palsama_________________      
  
1) Increases

2) Decreases

3) No change in BNP

4) None of the above


❂ What medication is used in tachycardia with Wolf Parkinson White syndrome?

1) Lidocaine

2) Disopyramide

3) Amiodarone

4) Verapamil


❂ Sotalol is a ___________________________________.

1) Class 1 Antidysrhythmic drug

2) Class 2 Antidysrhythmic drug

3) Class 3 Antidysrhythmic drug

4) Class 4 Antidysrhythmic drug


❂ Theophylline drug acts by ___________________________________.

1) Blocking Adenosine receptor

2) Stimulating Adenosine receptor

3) Stimulating Glutamate receptor

4) Blocking Glutamate receptor


❂  ______________ is used as an antidote in the treatment of methanol poisoning.
 
1) Chloroform

2) Ethyl alcohol

3) Formaldehyde

4) Acetaldehyde


❂ Which drug treatment is risky for a patient with seizures?

1) Nicotine

2) Buproprion

3) Mecamylamine

4) Disulfiram


❂ Disulfiram drug is contraindicated for ___________________patient.

1) Diabetes

2) Hepatitis

3) Meningitis

4) Hypotension


❂Except one the following drugs are used in opioid dependence:

1) α1 Agonists

2) α2 Antagonists

3) Opioid agonists or Partial agonists

4) Opioid long acting antagonist


❂ Which substance is a pure opioid agonist?

1) Dextropropoxyphene

2) Codeine

3) Methadone

4) Diamorphine


❂ Which folic acid antagonist has cytotoxic and immunosuppressant activity?

1) Sulfasalazine

2) Methotrexate

3) Azathioprine

4) Cyclophosphamide


❂ If NSAIDS are contraindicated in gout at this time another option is ______________medication.

1) Allopurinol

2) Colchicine

3) Probenecid

4) Sulphinpyrazone

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